Are Oxidative Stress-Activated Signaling Pathways Mediators of Insulin Resistance and -Cell Dysfunction?
نویسندگان
چکیده
منابع مشابه
Perspectives in Diabetes Are Oxidative Stress Activated Signaling Pathways Mediators of Insulin Resistance and -Cell Dysfunction?
In both type 1 and type 2 diabetes, diabetic complications in target organs arise from chronic elevations of glucose. The pathogenic effect of high glucose, possibly in concert with fatty acids, is mediated to a significant extent via increased production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and subsequent oxidative stress. ROS and RNS directly oxidize and damage...
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1 Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 2 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 3 Department of Preventive Medicine, School of Medicine, College of Medicine, Kyungpook National University, Daegu, Korea 4 Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuve...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2003
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.52.1.1